As we head into the final months of the year, we're excited to share a few updates from across the Addgene community.
This month, we're introducing a new option for requesting plasmids from Addgene, sharing an update on Addgene co-founder Melina Fan's new role, and taking you behind the scenes of one of the largest plasmid collections ever deposited in our repository.
Plus, we've got an upcoming webinar and a new Hot Plasmids for you to check out!
In this issue:
Now Available: Transfection-Ready DNA
Melina Fan transitions to Chief Scientific Advisor
Built to Share: Exploring the stories behind scientific resources
Hot plasmids: September edition
On-demand & upcoming webinars
Claim your Q4 coupon
Introducing Transfection-Ready DNA
Bacterial stabs have always been how Addgene ships plasmids, and they still are. But sometimes you just want the DNA. Starting this month, you can have exactly that with Transfection-Ready DNA, Addgene's new service that delivers NGS sequence-verified DNA ready to pipette upon arrival.
More than 27,000 of the 177,000+ plasmids in Addgene’s repository — spanning CRISPR, imaging and reporters, and gene expression — are eligible for the Transfection-Ready DNA service, with more added as the catalog grows each month.
It’s the same depositor-traceable (and often publication-backed) constructs researchers already request from Addgene, now in a format that gets you experimenting faster.
Addgene founders Kenneth Fan, Benjie Chen, and Melina Fan in 2014.
On August 1, Addgene co-founder and Chief Scientific Officer Melina Fan, PhD, transitioned to a new role as Chief Scientific Advisor, focused on science and strategy, after two decades of leadership with the organization.
During her tenure, Melina helped transform a common frustration at the bench into a global resource that has enabled scientific sharing and collaboration for researchers around the world. She also helped make depositing and sharing research materials a routine part of scientific practice while fostering the open-science community that continues to drive discovery today.
We’re grateful for everything Melina helped build at Addgene, and we’re glad she isn’t going far.
Built to Share: Exploring the Stories Behind Scientific Resources
Nyla Naim goes behind the scenes of the MORF Collection.
What does it take to share one of the largest plasmid collections ever deposited at Addgene? Find out in the first episode of Built to Share, our new video series exploring the science, stories, and people behind the tools that drive discovery.
We kicked things off with the MORF Collection, a deposit of nearly 3,500 transcription factor plasmids created by Julia Joung, PhD, in the Feng Zhang Lab at the Broad Institute of MIT and Harvard. Join Nyla Naim, PhD, from Addgene’s Scientific Applications team, as she takes you behind the scenes of bringing this massive resource online and reveals why sharing scientific tools at scale is so important for accelerating research.
Watch the first episode on YouTube and stay tuned for more stories from the scientists building resources for the global research community.
Beyond the Cut: Precision Editing for Disease Modeling
Presented by Elena Minones-Moyano, PhD (Director Product Management, Addgene)
Wednesday, October 28 | 12:00 PM ET / 9:00 AM PT
Researchers building disease models need precision. Learn how base editors, prime editors, and CRISPR-associated transposases (CAST) can create, correct, or insert genetic changes without double-strand breaks and how to choose the right approach for your disease-modeling goals.
How Well Do You Actually Know Your Plasmid? Long-Read Sequencing and What It Changes for Researchers
Presented by Cary Valley, PhD (Senior QC Manager, Addgene) and Valdemar Aksionov (Technical Sequencing Specialist, Plasmidsaurus)
An introduction to Sanger, short-read, and long-read sequencing, including what each approach reveals, its limitations, and how to choose the right method for your work.
CRISPR Pooled Libraries: Optimizing Knockout Library Design
Presented by Andrew Hempstead, PhD (Associate Director of Scientific Engagement and Success, Addgene) and Laura Drepanos (Computational Associate III, Broad Institute of MIT and Harvard)
An introduction to pooled library screens, followed by a deep dive into the new Julianna and Jacquere libraries from the Doench Lab.
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